HTP Analytical QC Associate Scientist

1d1 day ago

GenScript

Piscataway, US · Full-time · $60,000 – $75,000

About this role

GenScript is seeking a motivated and detail-oriented HTP Analytical QC Associate Scientist to join the dynamic US Protein Department. This role performs analytical characterization and quality control testing of recombinant proteins from high-throughput production workflows. It ensures protein identity, purity, and overall quality through robust methodologies.

The position involves executing protein characterization assays including HPLC/UPLC (SEC, RP, IEX), Capillary Electrophoresis (CE, iCE/cIEF), SDS-PAGE, Western blot, LC-MS, and endotoxin assays. Daily tasks include preparing samples, reagents, buffers, and standards per protocols, plus using automated liquid handling systems. Data analysis and documentation occur in ELN, LIMS, or equivalent systems following ALCOA+ principles.

This data-driven, quality-focused environment emphasizes accuracy, reproducibility, and data integrity. The Associate Scientist maintains laboratory instruments, supports calibration, and complies with quality and safety standards. Collaboration with cross-functional teams like protein production and process development drives project timelines.

Opportunities include method troubleshooting, optimization for robustness and consistency, and contributing to continuous improvement initiatives. Enhancements target workflow efficiency, method refinement, and data quality. The role supports GenScript's vision of reliable biotechnology for healthier humans and nature.

Requirements

BS or MS in Biochemistry, Analytical Chemistry, Biotechnology, or a related field with 2+ years of relevant experience in protein analytical characterization or QC
Hands-on experience with protein analytical techniques such as HPLC/UPLC, CE, SDS-PAGE, Western blot, LC-MS, or endotoxin assays
Familiarity with protein characterization workflows, including purity, aggregation, and identity analysis
Experience with laboratory data systems (ELN, LIMS, or similar) and strong documentation practices
Strong attention to detail and commitment to data integrity, accuracy, and reproducibility

Responsibilities

Perform routine and non-routine analytical and QC testing to evaluate protein identity, purity, and quality attributes
Execute protein characterization assays including HPLC/UPLC (SEC, RP, IEX), Capillary Electrophoresis (CE, iCE/cIEF), SDS-PAGE, Western blot, LC-MS, and endotoxin assays
Prepare samples, reagents, buffers, and standards in accordance with established protocols and assay requirements
Perform sample preparation workflows, including use of automated liquid handling systems
Analyze, interpret, and document experimental data in ELN, LIMS, or equivalent systems per data integrity standards
Support method troubleshooting and optimization for assay robustness, reproducibility, and consistency
Maintain laboratory instruments, ensure proper calibration and performance, and comply with quality and safety standards
Collaborate with cross-functional teams to support project timelines and contribute to continuous improvement initiatives