Research Scientist - Oligonucleotide Synthetic Chemistry

6d6 days ago

AstraZeneca

SE · Full-time · SEK 550,000 – SEK 750,000

About this role

Are you a passionate Scientist with expertise in synthetic chemistry and a great interest in the development of Oligonucleotide Therapeutics? Join our growing Oligonucleotide Chemistry team within the Nucleic Acid Therapeutics Department, part of Discovery Sciences R&D organization. You will have the opportunity to further exploit our drug discovery platforms.

Apply oligonucleotide synthetic chemistry knowledge to expand the use of oligonucleotides and molecular conjugates thereof. Support Hit Finding and optimisation of oligos in multiple projects for the treatment of diseases across therapy areas. Demonstrate passion for driving scientific questions with strong working ethics and team collaboration.

The Oligonucleotide Chemistry team works in close collaboration with Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences. Focus on designing and developing the oligonucleotide therapeutics of the future. Enjoy a highly rewarding scientific environment.

This lab-based oligo synthesis role aims to develop optimised oligonucleotides and oligo conjugates supporting the AstraZeneca pipeline. Work alongside experienced chemists to support project priorities. Propose experimental strategies and solve oligonucleotide synthetic challenges including method optimization on synthesizers.

Requirements

MSc in Organic Chemistry and hands-on experience of oligo synthesis
Ability to design and execute oligo synthesis experiments independently
Detailed knowledge of synthetic chemistry relating to oligonucleotides including method optimization on oligo synthesizers and troubleshooting
Knowledge of conjugating targeting moieties to different oligo-types
Design and synthesis knowledge within the oligonucleotide chemistry field, especially oligo synthesis, purification and analysis
Excellent English, both spoken and written
Recognized organic synthesis expertise and ability to apply analytical sciences
Ability to work independently in the oligo lab with a positive, result-oriented and problem-solving attitude

Responsibilities

Apply oligonucleotide synthetic chemistry knowledge to expand use of oligonucleotides and molecular conjugates
Support Hit Finding and optimisation of oligos in multiple projects
Develop optimised oligonucleotides and oligo conjugates to support the pipeline
Propose experimental strategies and solve oligonucleotide synthetic challenges
Perform method optimization on oligo synthesizers and troubleshooting
Plan, prioritize and perform own work independently
Collaborate with project team by driving problem solving using literature and own knowledge
Ensure high scientific standards and quality of compounds to meet project objectives