Principal Scientist - Analytical Chemistry

10h10 hours ago

Revolution Medicines

Redwood City, US · Full-time · $190,000 – $238,000

About this role

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company seeks a Principal Scientist to serve as Head of Analytical Chemistry within the Integrated Discovery Research team. This position drives analytical strategy supporting small molecule drug discovery programs from hit identification through candidate selection in the beyond Rule-of-Five space.

The role requires designing and leading analytical chemistry strategies and daily operations across multiple discovery stages. Responsibilities include developing robust methods using LC/MS, HPLC, SFC, and NMR for compound characterization, purity assessment, and stability studies. The scientist will also lead compound purification, chiral separations, and physicochemical property assessment.

You will collaborate closely with medicinal chemists, process chemists, and DMPK scientists to execute integrated analytical strategies. The position includes managing external service providers and ensuring high-quality data delivery while maintaining laboratory safety compliance. Additional focus involves implementing automated high-throughput methods through collaboration with LabOS and Data Sciences teams.

This opportunity offers the chance to shape analytical science at the frontiers of bRo5 drug discovery. The role includes mentoring a team of analytical chemists and contributing to invention disclosures, patent filings, and scientific publications. Success requires innovation and execution in fast-paced, data-driven research environments.

Requirements

Ph.D. in Analytical or Organic Chemistry or related discipline with 12+ years of industry experience.
Demonstrated expertise in advanced analytical method development, troubleshooting, and problem-solving in small molecule drug discovery.
Strong hands-on experience with chromatographic and spectroscopic techniques including LC/MS, HPLC, SFC, and NMR.
Proven experience supporting drug discovery programs across multiple modalities including small molecules, peptides, and ADCs.
Strong problem-solving skills with sound technically driven decision-making ability.
Excellent communication skills and the ability to drive cross-disciplinary partnerships.
A track record of innovation and execution in fast-paced, data-driven research environments.

Responsibilities

Design and lead analytical chemistry strategies and daily operations to support small molecule drug discovery programs across multiple stages.
Develop and implement robust analytical methods using LC/MS, HPLC, SFC for compound characterization, purity assessment, and stability studies.
Lead compound purification including chiral separations, structural elucidation, and physicochemical property assessment in the beyond Rule-of-Five space.
Collaborate with medicinal chemists, process chemists, and DMPK scientists to execute integrated analytical strategies.
Manage external analytical chemistry service providers to ensure high-quality, timely data delivery.
Mentor and develop a team of analytical chemists, fostering scientific excellence and professional development.
Design and implement automated high-throughput analytical methods through collaboration with LabOS, Data Sciences, and Data Analytics functions.