Research Scientist - Oligonucleotide Synthetic Chemistry

1w1 week ago

AstraZeneca

SE · Full-time · SEK 550,000 – SEK 750,000

About this role

Are you a passionate Scientist with expertise in synthetic chemistry and great interest in the development of Oligonucleotide Therapeutics? Join our growing Oligonucleotide Chemistry team within the Nucleic Acid Therapeutics Department in Gothenburg, Sweden. Apply oligonucleotide synthetic chemistry knowledge to expand use of oligonucleotides and molecular conjugates to support Hit Finding and optimisation across therapy areas.

This is a lab-based oligo synthesis role aimed at developing optimised oligonucleotides and oligo conjugates to support the AstraZeneca pipeline. Work alongside experienced chemists to support project priorities. Propose experimental strategies and creatively solve oligonucleotide synthetic challenges including method optimization on oligo synthesizers.

Plan, prioritize and perform own work while actively collaborating with project teams using literature and own knowledge. The team works closely with Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences. Focus on designing and developing the oligonucleotide therapeutics of the future in a highly rewarding scientific environment.

Demonstrate passion for driving scientific questions with strong working ethics and ability to work well within teams. Ensure high scientific standards and quality of compounds to meet project objectives. Build strong collaborative relationships to drive drug discovery projects forward.

Requirements

MSc in Organic Chemistry and hands-on experience of oligo synthesis
Ability to design and execute oligo synthesis experiments independently
Detailed knowledge of synthetic chemistry relating to oligonucleotides including method optimization on oligo synthesizers and troubleshooting
Knowledge of conjugating targeting moieties to different oligo-types
Design and synthesis knowledge within the oligonucleotide chemistry field, especially oligo synthesis, purification and analysis
Excellent English, both spoken and written
Recognized organic synthesis expertise and ability to apply analytical sciences

Responsibilities

Apply oligonucleotide synthetic chemistry knowledge to expand the use of oligonucleotides and molecular conjugates
Support Hit Finding and optimisation of oligos in multiple projects for treatment of diseases across therapy areas
Develop optimised oligonucleotides and oligo conjugates to support the AstraZeneca pipeline
Propose experimental strategies and creatively solve a wide range of oligonucleotide synthetic challenges
Perform method optimization on oligo synthesizers and troubleshooting
Plan, prioritize and perform own work independently
Actively collaborate with project team by driving problem solving using literature and own knowledge
Ensure high scientific standards and quality of compounds to meet project objectives

Benefits

Join a growing team with opportunity to further exploit drug discovery platforms
Highly rewarding scientific environment focused on oligonucleotide therapeutics