About this role
The Laboratory for RNA Delivery Therapeutics at NTU is seeking a post-doctoral Research Fellow to design and synthesize new lipids or polymers that are stimuli-responsive and suitable for nanoparticle delivery formulations. This role is part of a highly competitive large grant focused on improving RNA delivery vehicles for nanomedicine.
The Research Fellow will develop new stimuli-responsive lipid or polymer formulations for RNA nanomedicine, aiming to achieve efficient transfection efficiency and endosomal escape. Day-to-day work includes designing and synthesizing novel cationic or ionizable lipids or polymers, formulating them with RNA, and measuring transfection and endosomal escape efficiency along with other particle properties.
This research will be conducted in collaboration with top international scientists from MIT and Boston University, offering a unique opportunity to work at the forefront of RNA delivery science. The lab is directed by Prof Mary Chan-Park, a President Chair Professor and Director of the Centre for RNA Delivery Therapeutics at NTU Singapore.
As a Research Fellow, you will have the chance to contribute to urgently needed alternatives to current RNA delivery vehicles, with the goal of achieving greater delivery efficacy and fewer side effects. The role also involves supervising junior researchers, including PhD students, and leading technical aspects of the project.
Requirements
- PhD in Chemistry, Chemical Engineering, Materials Science, or related field
- At least 5 years of relevant hands-on experience in stimuli-responsive nanoparticle delivery formulations and evaluation
- Familiarity with stimuli-responsive RNA delivery formulations and evaluation (e.g., top research groups and classical LNP formulations)
- Proficiency in RNA formulation and RNA formulation evaluation
- Experience with mice studies and bioimaging (confocal, FRET, FRAP, etc.)
- Experience in lipid or polymer synthesis
- Competent in oral and written technical communications and technical leadership
- Ability to supervise junior researchers, like PhD students
Responsibilities
- Develop stimuli-responsive nanoparticle delivery formulations
- Develop optimum formulations for RNA delivery
- Design and synthesize new lipids or polymers
- Characterize nanoparticles
- Perform bioimaging of mammalian cells and delivery formulations
- Conduct mice studies
- Measure RNA transfection efficiency and particle properties
Benefits
- Work on a highly competitive large grant at the forefront of RNA nanomedicine
- Collaborate with top international scientists from MIT and Boston University
- Access to state-of-the-art laboratory facilities at NTU Singapore
- Opportunity to lead and supervise junior researchers in a dynamic academic environment
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