Process Development Chemist

23h23 hours ago

PolyPeptide Group

Torrance, US · Full-time · $65,000 – $85,000

About this role

The Development Chemist I supports peptide manufacturing by executing chemical synthesis, purification, and drying processes under established procedures and occasional supervision. This role monitors reactions, prepares solutions, operates HPLC systems, and performs in-process checks to ensure product quality. It upholds strict safety and cleanliness standards while aiding troubleshooting.

Daily tasks include checking reactor systems per SOP, measuring and mixing ingredients according to the BPR under direction. Chemists monitor chemical reactions for color and completeness, responding appropriately to maintain processing. They perform intermediate steps, prepare purification solutions, and conduct lyophilization and drying.

Purification involves using HPLC systems under occasional supervision to process crude peptides. In-process fractions undergo analytical HPLC checks, with results reported to supervision or senior chemists. Basic Go-No Go decisions guide processing, and equipment issues are reported with basic troubleshooting.

This position operates in a GMP manufacturing or laboratory environment, contributing to PolyPeptide’s quality and on-time delivery commitments. Team collaboration occurs under occasional supervision, fostering adaptability in shifting priorities. It emphasizes precise documentation and safety housekeeping for reliable peptide production.

Requirements

Bachelor's degree in chemistry or chemical engineering
2+ years of professional experience in pharmaceutical/biotechnology laboratory
Proficiency in HPLC systems
cGMP processes
Proficient use of Microsoft Office suite (Outlook, Excel, Word, PowerPoint, Teams)
Ability to work as part of a team and independently with minimal supervision
Impeccable technical writing skills with extreme attention to detail
Excellent organizational, multitasking, and communication skills

Responsibilities

Check reactor system for proper operation in accordance with SOP and operation manual
Measure and mix ingredients according to the BPR under occasional supervision
Monitor chemical reactions and respond with appropriate actions to ensure proper processing
Perform intermediate chemical processing steps using established procedures
Prepare solutions for purification
Purify crude peptide using HPLC under occasional supervision
Conduct lyophilization process according to established guidelines
Perform in-process checking of fractions by analytical HPLC and report results