Scientist - Process Chemistry

21h21 hours ago

Aralez Bio

Berkeley, US · Full-time · $95,000 – $120,000

About this role

Aralez Bio envisions a world improved sustainably by synthetic biology, producing thousands of noncanonical amino acids (ncAAs) with proprietary enzymes. Our manufacturing outperforms traditional approaches 10–100x, supplying Big Pharma for drugs like Ozempic. As Process Chemistry Scientist, drive production of ncAAs for next-generation therapeutics.

Spend up to 80% of time in the lab supporting manufacturing, including production, route development, process development, and scale-up. Optimize reactions and isolation processes for robust, scalable output meeting specifications. Author batch records, SOPs, and reports for reproducibility.

Collaborate with a diverse, passionate interdisciplinary team passionate about greener chemistries for drug manufacturing. Maintain high regard for safety, people, and ethical behavior. Thrive in an environment that values learning and creativity.

Unlock innovative products via chemistry and biocatalysis at various scales. Capitalize on vast growing ncAA catalog for clients. Continuously learn, improve, and excel in building a better world.

Requirements

PhD with 2+ years of experience or MS with 5+ years of experience; advanced degree in organic chemistry, chemical engineering, pharmaceutical chemistry, pharmaceutical science, or related
Hands-on experience and proven record in multi-step organic synthesis for small molecule, amino acid, or peptide production
Experience in product isolation including extractions, crystallization, precipitations, chromatography
Substantial experience with analytical techniques such as spectrophotometry, NMR, LC/MS, and HPLC
Experience in experimental design, DoEs for troubleshooting and process optimization
Experience in process development and scale-up
Excellent written and oral communication skills with exceptional interpersonal and management skills
Strong collaborative mindset, initiative, and ability to work independently

Responsibilities

Supply high quality non-canonical amino acids and derivatives for next generation therapeutics
Spend up to 80% of time in the lab supporting manufacturing activities, including production, route development, process development, and scale-up of ncAAs
Optimize reactions and isolation processes for robust and scalable production of products
Author, review, and maintain batch records, tech transfer documents, SOPs, and reports
Apply process and product characterization to collect data, quantify processes, and ensure specifications are met
Collaborate with multidisciplinary team to bring greener chemistries to drug manufacturing
Maintain high regard for safety, people, and ethical behavior