Senior Principal Scientist - Discovery Process Chemistry

15h15 hours ago

Bayer

Wuppertal, DE · Full-time · €110,000 – €150,000

About this role

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all, Hunger for none' is no longer a dream. As a Senior Principal Scientist in Discovery Process Chemistry, you will lead internal and external early API development and supply activities to support lead optimization, preclinical, and early clinical R&D/CMC teams. You handle chemical route design, process optimization, and supply for small molecule drug candidates and building blocks at external partners.

Your role generates benefits in yield, quality, and cost for small molecules of high complexity and synthetic modalities such as peptides. You ensure the competitiveness of production processes by evaluating and applying new and state-of-the-art chemical technologies. Responsibilities include leading chemical process R&D activities in collaboration with external partners.

You collaborate closely in interdisciplinary project teams within Pharmaceutical Sciences and across the Bayer-wide chemistry community. Manage complex API projects at suppliers with a high degree of independence and appropriate alliance management. Drive excellence in synthetic chemistry through expertise and quick troubleshooting solutions.

Develop and optimize methods, models, and processes according to the latest advancements in process chemistry and technologies. Present findings and progress updates to internal stakeholders and at external conferences and workshops. Build a varied and meaningful career in a community of brilliant and diverse minds.

Requirements

PhD in organic chemistry or related discipline with profound knowledge of classical and modern synthetic methods & technologies, with knowledge of modern tools in digital chemistry as a plus
Long-term experience in process chemistry and relevant technologies, ideally at the interface of research & development in the pharmaceutical industry
Experience in managing external partners or working at a CRO/CDMO
High ability to solve problems and structure and simplify complex tasks
Strong interpersonal and influencing leadership skills and intercultural competences, with the ability to build trustful relationships and motivate team members
Excellent presentation and communication skills, including the ability to communicate across multiple levels within and outside the organization
High assertiveness, service orientation, and enjoyment of working in a cross-functional team
Excellent English communication skills, both verbal and written, fluency in German is advantageous

Responsibilities

Lead chemical process R&D activities, including route design, process development, and supply activities in collaboration with external partners
Perform assessments of chemical routes and manufacturing & supply concepts
Manage complex API projects at suppliers with a high degree of independence, ensuring appropriate alliance management
Collaborate closely in interdisciplinary project teams
Develop and optimize methods, models, and processes according to the latest advancements in process chemistry and technologies
Drive excellence in synthetic chemistry within Pharmaceutical Sciences and across the Bayer-wide chemistry community
Provide chemical expertise and consultancy, proposing quick solutions in troubleshooting within the internal and external network
Present findings and progress updates to internal stakeholders and at external conferences and workshops