About this role
Calico Life Sciences is an Alphabet-founded research company harnessing advanced technologies and model systems to understand the biology of human aging. The mission is to devise interventions enabling longer, healthier lives through innovative labs and a vibrant drug-development pipeline with partners. Seeking an experienced Process Chemist for the laboratory-based chemical development team with hands-on process research, route scouting, and scale-up expertise.
In this lab-focused role, design, optimize, and execute synthetic processes for efficient, safe, scalable manufacturing of small-molecule intermediates and APIs. Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control. Conduct detailed reaction analysis using HPLC, GC, LC-MS, and other techniques while identifying impurities.
Identify and mitigate process risks related to safety, scalability, and robustness. Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance. Prepare clear, data-driven reports, present results to project teams, and support technology transfer to contract manufacturing organizations.
Translate laboratory findings into robust processes within Calico’s commitment to curiosity-driven discovery science. Contribute to an inspiring environment catalyzing medical breakthroughs. Maintain accurate lab documentation and adhere to safety and compliance standards in a highly innovative setting.
Requirements
- M.S. in Organic Chemistry or related field with 14+ years of relevant industrial experience in process chemistry
- Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
- Demonstrated success in developing scalable synthetic processes
- Proficiency with standard analytical instruments and data interpretation
- Excellent problem-solving, organization, and communication skills
- Ability to work independently while contributing effectively to a team environment
- Familiarity with cGMP and ICH guidelines
- Must be willing to work onsite 5 days a week
Responsibilities
- Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
- Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
- Conduct detailed reaction analysis using HPLC, GC, LC-MS, and other analytical techniques
- Perform impurity identification and synthesis
- Identify and mitigate process risks related to safety, scalability, and robustness
- Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance
- Prepare clear, data-driven reports and present experimental results to project teams
- Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
Benefits
- Estimated base salary range of $163,000 - $201,000
- Actual pay based on experience and qualifications
- Eligible for two annual cash bonuses
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