About this role
The Chemical Process and Analytical Development (CPAD) group develops innovative and phase-appropriate synthetic routes and scalable chemical processes for novel small molecule components in targeted therapeutics. Process chemists, analytical scientists, and chemical engineers collaborate to design robust, safe, and scalable chemistry that accelerates delivery of life-changing therapeutics to patients.
As Senior Principal Scientist in Process Chemistry, you will serve as a key technical leader driving route scouting, synthetic design, process development, and process characterization for an expanding portfolio. Apply a strong foundation in modern synthetic organic chemistry and process research to design scalable, innovative synthetic processes using HTE, data-rich experimentation, continuous processing, catalysis, and predictive software.
This role offers hands-on laboratory innovation while guiding technical strategy for early and late-stage programs. Mentor junior scientists, lead cross-functional project direction, and represent process chemistry internally and externally. Oversee execution of GMP production batches through technology transfer and campaign oversight.
Lead technical teams to execute complex experiments for route development and scale-up. Foster an inclusive, scientifically rigorous, and collaborative environment. Maintain an external technical presence through publications and presentations.
Requirements
- PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing; or Master’s degree with 15+ years of relevant experience
- Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies
- Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations
- Strong communication skills with demonstrated collaborative leadership in cross-functional process development teams
- Experience supporting development from preclinical through commercial stages
- Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions
- This is an on-site role (5 days/week)
- Submission of a research summary is required
Responsibilities
- Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale-up
- Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability
- Lead authorship of patents, publications, and regulatory documents
- Apply modern synthetic organic chemistry principles, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development
- Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions
- Drive alignment to project timelines and portfolio strategy
- Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment
- Lead technology transfer and partner interactions to enable external development campaigns
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