About this role
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on targeted protein degradation medicines for cancer and inflammatory diseases. Powered by AI-integrated discovery and ligase expertise, it advances degrader-based treatments. Seeking a talented synthetic organic chemist for the medicinal chemistry group.
This role involves designing and synthesizing novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy. Engage in rational structure-based drug discovery with computational and structural biology groups. Pursue degrader-based small molecules for unmet medical needs.
Join a dynamic multi-disciplinary team collaborating with Nurix scientists and external partners. Contribute to patent writing, reports, and scientific publications. Initiate and lead process improvements in chemistry or cross-functionally.
Build inventive contributions to new chemical targets and evaluate screening or literature hits. Demonstrate leadership in cross-functional teams. Thrive in a solutions-oriented, hands-on environment advancing drug discovery programs.
Requirements
- Ph.D. in synthetic organic chemistry with 8 – 10+ years pharmaceutical medicinal chemistry industrial experience
- Track record of delivering advanced leads/development candidates
- Excellent knowledge of medicinal chemistry principles with solid understanding of biology, pharmacology, ADME concepts, and series SAR
- Strong working knowledge of protein-ligand interactions, conformational and structural analysis
- Experienced in partnering closely with computational chemists using computational tools, models and visualization applications
- Expert in organic synthesis, knowledgeable of current literature, with strong synthetic problem-solving skills
- Proven leadership capability in a cross-functional team setting as project team leader or co-lead
- Excellent communication skills and ability to present rationale, key data, issues and accomplishments
Responsibilities
- Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy
- Engage in rational structure-based drug discovery enabled by computational and structural biology groups
- Collaborate with a broad group of scientists within Nurix and with external collaborators
- Contribute to patent, report and scientific publication writing
- Initiate and/or lead process improvements within the chemistry department or cross-functionally
- Make inventive contributions towards new chemical target structures or templates for programs
- Evaluate early screening or literature hits
Similar roles
Senior Principal Scientist - Discovery Process Chemistry
20h20 hours agoBayer
Wuppertal, DE · Full-time · €110,000 – €150,000
Polymer Engineer
20h20 hours agoShellworks
London, GB · Full-time · £30,000 – £40,000
Scientist Organic Chemist - Process Chemistry
20h20 hours agoSanofi
Montpellier, FR · Full-time · €42,400 – €56,533
Senior/Principal Scientist - Synthetic Molecule Analytical Chemistry
20h20 hours agoGenentech
South San Francisco, US · Full-time · $124,300 – $265,900