Senior/Principal Scientist - Synthetic Molecule Analytical Chemistry

15h15 hours ago

Genentech

South San Francisco, US · Full-time · $124,300 – $265,900

About this role

We advance science so that we all have more time with the people we love. A healthier future drives us to innovate and ensure access to healthcare. Genentech seeks a Senior/Principal Scientist for the Synthetic Molecule Analytical Chemistry group to solve complex analytical challenges across discovery through clinical development.

This role suits a scientist who thrives at the bench, advancing a diverse pipeline of synthetic small molecules, peptides, oligonucleotides, and drug delivery systems like lipid nanoparticles. Responsibilities include designing and troubleshooting analytical methods using high resolution mass spectrometry, UHPLC, 2D-LC/MS, and other state-of-the-art technologies. Expertise in HRMS, MS/MS, and chromatographic separations addresses drug discovery and development problems.

Work in a highly collaborative, cross-functional environment partnering with process development, formulation, safety science, and quality teams. Develop control strategies aligned with cGMP, ICH, and regulatory expectations. Contribute high-quality data to inform molecular and formulation decisions across programs.

Innovate by evaluating new technologies in analytical chemistry and materials characterization. Author sections for regulatory submissions and prepare data packages for health authority interactions. Maintain a high-level scientific profile through pipeline contributions and scholarly achievements.

Requirements

PhD in Analytical Chemistry, Pharmaceutical Sciences, Materials Sciences, Bioengineering, or relevant scientific disciplines with 0-2 years industry experience (Senior Scientist); 3-5 years of industry experience (Principal Scientist). Exceptional candidates with Bachelor or Master degree in these fields with 12+ years of experience may be considered
Outstanding record of innovation and success in multiple projects over the course of graduate, post-doctoral and industrial career with a sustained publication or patent record
Deep hands-on expertise in at least one of the following areas for the analysis of synthetic small molecules, peptides, oligonucleotides, polymers, or nanoparticles: Mass spectrometry method development (HRMS, MS/MS, structural elucidation); Chromatographic method development (reversed phase, normal phase, HILIC, SEC, SFC, 2D-LC/MS)
Experience with chromatography and/or MS data systems (e.g., Empower, Xcalibur, MassHunter, Chromeleon), and ability to independently analyze complex datasets

Responsibilities

Designing, developing, and troubleshooting analytical methods from first principles, including sample preparation, method optimization, and data interpretation with state-of-the-art technologies like HRMS, UHPLC, 2D-LC/MS, GC/MS, light scattering, spectroscopy, rheology, microscopy
Applying and deepening expertise in HRMS, MS/MS, and/or chromatographic separations to solve complex analytical problems during drug discovery/development
Contributing to regulatory submissions, including authoring sections and preparing data packages for health authority interactions
Partnering with cross-functional teams (process development, formulation, safety science, quality, etc.) to develop control strategies aligned with cGMP, ICH, and regulatory expectations
Informing program decisions across discovery and early development by generating high-quality data to guide molecular and formulation decisions
Innovating and evaluating new technologies in analytical chemistry or materials characterization to enable integration of state-of-the-art instrumentation and software
Maintaining a high-level scientific profile both internally and externally in terms of pipeline contributions and scholarly achievements