Scientist - Medicinal Chemistry

6d6 days ago

Amgen

Thousand Oaks, US · Full-time · $111,695 – $151,117

About this role

At Amgen, join the shared mission to serve patients living with serious illnesses. As part of the innovative Medicinal Chemistry group, design, synthesize, and purify novel compounds for potential clinical drug development. Contribute to the Induced Proximity Platform focused on PROTAC modality for intractable targets.

Develop, implement, and perform organic reactions for Medicinal Chemistry teams, including troubleshooting synthetic routes and scouting new routes. Perform high difficulty synthetic chemistry and contribute to designing new compounds with structure-activity relationships. Conduct structural determinations using NMR and mass spectral techniques while purifying compounds.

This onsite laboratory position at Thousand Oaks involves working in teams as a recognized lab leader. Demonstrate excellent verbal and written communication skills. Maintain laboratory notebooks, participate in group and project meetings, present to groups, and aid in papers and patent applications.

Thrive in Amgen’s award-winning collaborative, innovative, and science-based culture. Help research, manufacture, and deliver innovative medicines across Oncology, Inflammation, General Medicine, and Rare Disease. Transform patient lives while advancing your career through passion for challenges.

Requirements

Doctorate Degree
Master’s degree and 2 years of laboratory experience
Bachelor’s degree and 4 years of laboratory experience
Track record of accomplishments (e.g., peer-reviewed publications)
Demonstrated ability to scout and troubleshoot synthetic routes, and perform high difficulty synthetic chemistry
Clear understanding of structural determination using NMR and Mass Spectral techniques as well as knowledge of purification methods
Demonstration of good lab practices, with particular attention to safety
Excellent communication skills (both written and oral), leadership skills and the ability to work well in teams

Responsibilities

Design, synthesize, and purify novel compounds for potential clinical drug development
Work within Amgen’s Induced Proximity Platform (IPP) using PROTAC modality
Develop, implement, and perform organic reactions for Medicinal Chemistry teams
Troubleshoot synthetic routes and reactions, scout new synthetic routes
Perform high difficulty synthetic chemistry
Contribute to the design of new compounds and development of structure-activity relationships
Perform structural determinations using NMR and mass spectral techniques
Purify compounds using a variety of techniques