Senior Scientist - Medicinal Chemistry, Oncology Targeted Discovery

1d1 day ago

AstraZeneca

Waltham, US · Full-time · $118,870 – $178,306

About this role

Be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer. At AstraZeneca, turn ideas into life changing medicines with a pioneering oncology pipeline enabled by transformative technologies. Working here means being ambitious, thinking big and working together to make the impossible a reality for patients.

As a Senior Scientist within the Oncology Targeted Discovery chemistry group, play an important role in advancing new oncology drug projects to make a positive impact on patients’ lives. This is a hands-on laboratory position within a world leading global medicinal chemistry group. Deliver highly specific therapeutics including small molecules, peptide and antibody drug conjugates with various targeting modalities to treat cancer.

Work both independently and as a team member, collaborating with colleagues across drug discovery functions, including computational chemistry and high-throughput experimentation. The Waltham R&D site is home to Oncology Targeted Discovery chemistry research. Build strong research teams that embrace the diversity of talents of team members.

Understand the importance of flexibility in the work-life environment with a wide variety of benefits, services and programs. Provide employees with the resources they need to pursue work goals and life goals. Grow and learn together to accomplish the collective goal to improve human health.

Requirements

Doctoral degree (Ph.D.) or equivalent focused in synthetic organic chemistry with 0+ years of relevant experience
A strong track record of scientific innovation and success documented through peer-reviewed publications
Expert knowledge of organic synthesis and methodology, with sound understanding of reaction mechanisms and awareness of latest scientific literature
Strong work ethic and adherence to safe practices in the laboratory
Desire to grow and develop as a synthetic/medicinal chemist

Responsibilities

Design and execute synthetic routes to prepare complex target molecules for tumor-targeted delivery programs
Develop creative approaches to overcome challenging synthetic chemistry problems
Analyze data and interpret structure activity relationships (SAR) to rationally design new targets
Work both independently and as a team member, collaborating with colleagues across drug discovery functions, including computational chemistry and high-throughput experimentation
Contribute to patent applications and scientific publications
Stay current with new developments in synthetic organic chemistry and medicinal chemistry
Act in accordance with all AstraZeneca policies, including personnel guidelines, EHS regulations, best laboratory practices, and the Code of Conduct