About this role
At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve pioneered biotech against tough diseases, focusing on Oncology, Inflammation, General Medicine, and Rare Disease. Join our award-winning, collaborative, innovative, science-based culture.
We seek a highly skilled organic chemist to develop next-generation RNA therapeutics as part of the oligonucleotide delivery team. Utilize state-of-the-art methods to design and prepare novel delivery ligands, conjugation linkers, and nucleotides. Chemically modify oligonucleotides for enhanced delivery and efficacy.
The role involves a diverse organic chemistry skillset with experience in small molecule and carbohydrate synthesis. Interact with oligonucleotide chemists, conjugation chemists, protein chemists, and biologists. Help discover novel delivery mechanisms and contribute to our therapeutic RNA pipeline.
Our collaborative culture supports professional and personal growth. Transform patient lives while advancing your career in a dynamic environment. Benefit from a Total Rewards Plan including health, financial, work/life balance, and development opportunities.
Requirements
- Doctorate degree (PhD, PharmD, or MD)
- Master’s degree and 3 years of relevant experience
- Bachelor’s degree and 5 years of relevant experience
- Ph.D. in synthetic organic chemistry or related discipline
- Postdoctoral or >2 years industry experience in small molecule or carbohydrate synthesis
- Hands-on laboratory experience preparing diverse synthetic compounds
- Experience with state-of-the-art techniques and characterization of synthetic molecules
- Ability to conduct independent research in a dynamic environment
Responsibilities
- Develop the next generation of RNA therapeutics
- Design novel delivery ligands for oligonucleotide modification
- Prepare conjugation linkers to enhance oligonucleotide delivery
- Synthesize modified nucleotides using state-of-the-art methods
- Chemically modify oligonucleotides for improved efficacy
- Conduct small molecule and carbohydrate synthesis
- Collaborate with oligonucleotide, conjugation, protein chemists and biologists
- Contribute to discovery of novel delivery mechanisms
Benefits
- Health and welfare plans for staff and eligible dependents
- Financial plans with opportunities to save towards retirement or other goals
- Work/life balance initiatives
- Career development opportunities
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