About this role
Abiologics, Inc., founded in Flagship Pioneering’s venture creation engine, pioneers Synteins™, a transformational class of macromolecular medicines using novel synthetic and computational technologies. We seek an experienced Senior Scientist in Medicinal Chemistry specializing in miniprotein and peptide drugs. This role leads projects designing, synthesizing, and optimizing novel Syntein therapeutics from early-stage research to clinical development.
The successful candidate will independently plan, execute, interpret, and optimize Syntein structure-activity campaigns through direct, hands-on laboratory work. Implement modern peptide chemistry and conjugation methodologies to accelerate miniprotein drug development optimization. Drive bench-side innovation ensuring ideas transition seamlessly from concept to reality.
Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success. Mentor and guide junior scientists, fostering a collaborative and dynamic laboratory environment. Contribute to patent applications and scientific publications showcasing lab innovation.
Join a mission-driven biotech passionate about therapeutic modality innovation, backed by Flagship Pioneering which has originated over 100 ventures including Moderna. Advance miniprotein drugs toward clinical impact in a setting recognized for transforming human health. Work on-site in Boston to enable bigger leaps in biotechnology.
Requirements
- Ph.D. (with a minimum of 5 years of industry experience) or M.S. (with a minimum of 12 years of industry experience) in Medicinal Chemistry, Synthetic Organic Chemistry, Chemical Biology, or related field
- Strong track record of laboratory-based innovation and problem-solving in drug discovery including optimization of affinity, selectivity, drug properties, and PK profile
- Proven expertise in the hands-on peptide synthesis
- Ability to lead and inspire a team of scientists in a dynamic research setting
- Excellent communication skills for both technical and non-technical audiences
- Able to work on-site and attend in-person meetings
Responsibilities
- Independently plan, execute, interpret, and optimize Syntein structure-activity campaigns through direct, hands-on laboratory work
- Implement modern peptide chemistry and conjugation methodologies to accelerate optimization of miniprotein drug development
- Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success
- Drive bench-side innovation, ensuring that ideas transition seamlessly from concept to reality
- Mentor and guide junior scientists, fostering a collaborative and dynamic laboratory environment
- Contribute to patent applications and scientific publications, showcasing lab innovation
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