Scientist - Medicinal Chemistry

6d6 days ago

Amgen

South San Francisco, US · Full-time · $128,577 – $173,957

About this role

At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve pioneered biotech against tough diseases in Oncology, Inflammation, General Medicine, and Rare Disease. Join the team to research, manufacture, and deliver innovative medicines.

In this vital role, be part of an innovative Medicinal Chemistry group designing, synthesizing, and purifying novel compounds for clinical drug development. Work within Amgen’s Induced Proximity Platform (IPP) on PROTAC modality to modulate intractable targets. This is an onsite laboratory position at South San Francisco.

Thrive in an award-winning collaborative, innovative, science-based culture passionate for challenges. Work in teams developing organic reactions, troubleshooting routes, and scouting new syntheses. Demonstrate lab leadership with excellent verbal and written communication.

Transform lives of patients while transforming your career. Contribute to structure-activity relationships and structural determinations using NMR and mass spec. Participate in meetings, maintain notebooks, and aid papers and patents.

Requirements

Doctorate Degree
Master’s degree and 2 years of laboratory experience
Bachelor’s degree and 4 years of laboratory experience
Track record of accomplishments (e.g., peer-reviewed publications)
Demonstrated ability to scout and troubleshoot synthetic routes, and perform high difficulty synthetic chemistry
Clear understanding of structural determination using NMR and Mass Spectral techniques as well as knowledge of purification methods
Demonstration of good lab practices, with particular attention to safety
Excellent communication skills (both written and oral), leadership skills and the ability to work well in teams

Responsibilities

Design, synthesize, and purify novel compounds for potential clinical drug development
Work within Amgen’s Induced Proximity Platform (IPP) focused on PROTAC modality
Develop, implement, and perform organic reactions for Medicinal Chemistry teams
Troubleshoot synthetic routes and reactions, scout new routes, perform high difficulty synthetic chemistry
Contribute to design of new compounds and development of structure-activity relationships
Perform structural determinations using NMR and mass spectral techniques
Purify compounds using a variety of techniques
Maintain laboratory notebooks, participate in group and project meetings, present to groups, aid in writing papers and patent applications