About this role
We are seeking a talented and passionate scientist to join our dynamic, fast-paced, and collaborative team. Using strong organic synthesis skills, you will contribute to developing and supporting novel chemistry solutions for the advancement of our RNAi platform.
In this onsite role based in Cambridge, MA, you will develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA. Your day-to-day work involves multi-step synthesis, purification, and structural analysis of intermediate compounds, as well as troubleshooting and maintaining critical instrumentation such as NMR, HPLC, and LCMS.
You will work closely with internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA. The successful candidate will have a strong background in synthetic organic chemistry with a creative mindset, independent problem-solving ability, and a desire to enable discoveries at the bench.
This role offers the opportunity to apply your knowledge to new areas of study and thrive in a team environment. You will analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate results at internal meetings.
Requirements
- B.S./M.S. in Chemistry with 2-3 years of industrial experience in Medicinal Chemistry
- Demonstrated ability to understand reaction mechanism and chemical reactivity in Organic Chemistry
- Strong laboratory skills in synthesis, purification, and characterization of small molecules
- Expertise in state-of-the-art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data
- Must be flexible to apply knowledge to new areas of study and thrive in a team environment
- Excellent written and oral communication skills
Responsibilities
- Develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA
- Perform multi-step synthesis, purification, and structural analysis of intermediate compounds
- Synthesize organic building blocks to be used for RNA delivery
- Work closely with internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA
- Troubleshoot and perform routine maintenance on critical instrumentation such as NMR, HPLC, LCMS and other instruments in the lab
- Analyze, interpret, and organize data to prepare clearly articulated experimental reports
- Communicate results of projects at internal meetings
Benefits
- Annual short-term incentive award (bonus or sales incentive)
- Annual long-term incentive award (equity)
- Comprehensive medical, dental, and vision coverage
- Life and disability insurance
- Lifestyle reimbursement program
- Flexible spending and health savings accounts with 401(k) and generous company match
- Paid time off, wellness days, holidays, and two company-wide recharge breaks
- Generous family resources and leave
Similar roles
Postdoctoral Fellow - Bioorganic Chemistry
2w2 weeks agoRoche
Penzberg, DE · Full-time · €55,000 – €65,000
Analytical Chemistry Co-op
2w2 weeks agoLila Sciences
Cambridge, US · Full-time · $45,000 – $60,000
Post-Doctoral Associate - Synthetic Organic Chemistry
4w1 month agoUniversity of Florida
Gainesville, US · Full-time · $55,000 – $65,000
Principal Research Associate - Analytical Chemistry
5w1 month agoVertex
San Diego, US · Full-time · $85,700 – $128,500