Postdoctoral Fellow - Bioorganic Chemistry

2w2 weeks ago

Roche

Penzberg, DE · Full-time · €55,000 – €65,000

About this role

Roche is seeking a highly talented and motivated postdoctoral fellow to join the Chemistry Technologies department in Penzberg, Germany. This role focuses on developing novel reagents and workflows for next-generation sequencing, leveraging modern synthetic and analytical methods to design tailor-made molecules for diagnostic questions and beyond.

In this position, you will design and synthesize complex oligonucleotide-conjugates using contemporary bioconjugation techniques and small molecular entities by chemical synthesis. You will establish DNA templated proximity reactions for initial testing of new reagent classes and collaborate proactively with project partners from biology, analytics, and sequencing test development teams.

Our culture is defined by trust, transparency, and a strong collaborative spirit. We are driven by passion for science and commitment to continuous learning to stay at the forefront of research, working as a cross-functional team where every voice matters.

This position is part of the Roche Diagnostics Postdoc Program, offering the opportunity to present scientific progress through internal meetings and scientific conferences. The role is limited to 2 years, starting September 2026, and provides a platform to innovate healthcare through cutting-edge chemical research.

Requirements

PhD in the field of (bio)organic chemistry, chemical biology or life science
Profound knowledge in the synthesis of oligonucleotide-conjugates, preferably in context of biomolecules (proteins, peptides, nucleic acids)
Well experienced in organic synthesis
Hands-on experience in the field of DNA-templated reactions, proximity reactions and nucleic acid detection
At least one first author paper published or accepted in a high impact journal
Excellent communication and interpersonal skills with sensitivity to intercultural and interdisciplinary matters
Excellent English skills required; German is not mandatory

Responsibilities

Design and synthesize complex oligonucleotide-conjugates by contemporary bioconjugation techniques and small molecular entities by chemical synthesis
Establish DNA templated proximity reactions for initial testing of new reagent classes
Collaborate proactively with project partners from biology, analytics and the sequencing test development teams to gain deep insight into the relationship of structural design and assay performance
Independently plan, execute and analyze experiments to effectively advance the projects
Present scientific progress through internal meetings and visit scientific conferences to ensure state-of-the-art knowledge in bioorganic synthesis, chemical biology and surface chemistry
Be part of a highly motivated and cross-functional team

Benefits

Opportunity to innovate healthcare through the Roche Diagnostics Postdoc Program
Culture defined by trust, transparency, and a strong collaborative spirit
Access to state-of-the-art synthetic and analytical methods
Opportunity to present at scientific conferences and internal meetings