Director / Senior Director, Bioconjugation and Biopolymer Engineering

1d1 day ago

RA Capital Management

Boston, US · Full-time · $275,000 – $425,000

About this role

Zyphore is a cutting-edge biotechnology company focused on developing enzyme-based therapeutics to address metabolic diseases. It leverages proprietary enzyme engineering, half-life extension (HLE), and immunogenicity shielding technologies to revolutionize enzyme-based therapeutics and provide best-in-class solutions. The Director / Senior Director will lead development and optimization of half-life extension strategies to enhance enzyme stability, activity, and immune shielding.

This role oversees the design, execution, and translation of conjugation technologies, ensuring alignment with Zyphore’s pipeline and platform goals. Daily work involves advancing precision biopolymer conjugation and fusion strategies to overcome immunogenicity and clearance challenges. Responsibilities include implementing site-specific conjugation, PEGylation, and glycoengineering methodologies.

Collaborate with cross-functional teams in protein engineering, enzyme screening, and translational science to integrate bioconjugation across the R&D pipeline. Manage external partnerships with CDMOs for technology innovation. Operate within Raven, RA Capital’s healthcare incubator, supported by experienced scientists and operators with deep sector expertise.

Raven turns scientific breakthroughs into transformative therapies, from discovery to delivery. Join a platform that accelerates innovative companies with RA Capital’s $10 billion assets under management. Contribute to evidence-based investing in healthcare and life sciences for patient impact.

Requirements

Deep expertise in biopolymer conjugation chemistry such as biologic PEGylation, antibody-drug conjugates (ADCs), biopolymer synthesis, and biopolymer analytical methods
Proven ability to lead cross-functional scientific teams
Background in glycobiology, glycoengineering, chemical biology, carbohydrate synthesis, and synthetic biology
Emphasis on site-directed conjugation methods
Experience overseeing design, execution, and translation of conjugation technologies
Knowledge of analytical method development for enzyme activity and PK/PD properties

Responsibilities

Lead the development of novel conjugation chemistries to optimize enzyme-based therapeutics, focusing on stability, targeted delivery, and half-life extension
Advance precision biopolymer conjugation and fusion strategies to overcome immunogenicity and clearance challenges
Oversee the design and execution of analytical assays to assess enzyme activity post-conjugation and PK/PD properties
Implement state-of-the-art conjugation methodologies, including site-specific conjugation, PEGylation, and glycoengineering
Collaborate with internal teams, including protein engineering, enzyme screening, and translational science, to integrate bioconjugation solutions across the R&D pipeline
Identify and manage collaborations with CDMOs