Senior Scientist - Medicinal Chemistry

6d6 days ago

Ionis Pharmaceuticals

Carlsbad, US · Full-time · $127,775 – $162,528

About this role

Headquartered in Carlsbad, California, Ionis has discovered medical breakthroughs for more than three decades. We’re pioneers in RNA-targeted medicines revolutionizing drug discovery for patients with unmet needs. Our platform drives innovation with multiple marketed medicines and a leading pipeline in neurology and cardiology.

We seek a motivated Senior Scientist for our Medicinal Chemistry team to synthesize ligands or nucleoside monomers. Incorporate them into therapeutic oligonucleotides and perform bioconjugation to ligands targeting cell surface receptors. This role contributes to breakthrough therapies transforming patients’ lives.

Ionis cultivates a challenging, motivating environment fostering innovation and scientific excellence. Our success results from exceptional talents and dedication of employees. We invest in onsite, hybrid, and remote work environments where relationships thrive.

Join our exceptional team to change the course of human health with diverse perspectives. Experience our unique culture while developing your career. Contribute to meaningful impact on patients in need through RNA therapies and gene editing.

Requirements

Ph.D. in Organic or Nucleic Acid Chemistry with at least 2 years of post-doctoral experience in academia or industry
Experience in nucleoside/oligonucleotide synthesis and purification
Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
Experience with automated lab equipment (e.g., NMR, LC-MS)
Track record of scientific productivity as evidenced by high quality publications and/or patents
Excellent communication skills and ability to succeed in a team environment
Ability to be productive in a fast-paced, interactive, and innovative work environment

Responsibilities

Synthesize ligands or nucleoside monomers
Incorporate ligands or nucleoside monomers into therapeutic oligonucleotides
Perform bioconjugation of oligonucleotides to ligands targeting cell surface receptors
Purify nucleosides and oligonucleotides using ion exchange, reverse-phase, and size-exclusion chromatography
Characterize compounds with automated lab equipment such as NMR and LC-MS
Collaborate with cross-functional teams on research and development of RNA-targeted therapies