Principal Scientist - Analytical Chemistry

1d1 day ago

Johnson & Johnson

Turnhout, BE · Full-time · €90,000 – €140,000

About this role

Johnson & Johnson Innovative Medicine develops treatments that improve health worldwide across neurologic disorders, oncology, and more. The Chemical Process Research & Development (CPRD) department focuses on synthetic methodologies for small molecules, oligonucleotides, peptides, and ADCs. Process Analytical Research (PAR) provides analytical data and expertise for all chemical process activities.

As Principal Scientist, provide advanced analytical characterization and problem-solving using HRMS workflows across the portfolio. Partner closely with process chemists and cross-functional stakeholders. Act as project analyst to drive execution, prioritization, and communication of analytical strategy and results.

Operate in an inclusive work environment guided by Our Credo, respecting diversity and individual merit. Contribute to world-class API production processes enhancing efficiency, safety, cost-effectiveness, regulatory compliance, and environmental impact. Specialize in HRMS for small molecules, peptides, oligonucleotides, and bioconjugates including ADCs.

Enable broad portfolio impact and digital enablement through state-of-the-art analytical methods. Generate and document essential end-to-end knowledge for chemical process development. Innovate across healthcare solutions to profoundly impact health for humanity.

Requirements

Expertise in High-Resolution Mass Spectrometry (HRMS) applied across modalities including small molecules, peptides, oligonucleotides, and bioconjugates including ADCs
Strong interest in broad portfolio impact and digital enablement
Ability to provide analytical data and expertise for chemical process development
Experience operating as scientific leader partnering with process chemists
Proficiency in HRMS workflows for advanced characterization and problem-solving
Knowledge of ensuring regulatory compliance and minimizing environmental impact in API production

Responsibilities

Develop and apply HRMS-based methods to characterize materials across small molecules, peptides, oligonucleotides, and bioconjugates
Provide advanced analytical characterization and problem-solving using HRMS workflows to support chemical process development
Partner closely with process chemists and cross-functional stakeholders as a scientific leader
Act as project analyst to drive execution, prioritization, and clear communication of analytical strategy and results
Design and implement state-of-the-art analytical methods to ensure quality and performance
Generate and document essential end-to-end knowledge for chemical process activities
Refine synthetic routes and scale up processes from laboratory to commercial levels