Senior/Principal Scientist - Medicinal Chemistry

6d6 days ago

Flagship Pioneering, Inc.

Cambridge, US · Full-time · $126,000 – $214,500

About this role

What if you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability? Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. We create small molecules that edit protein structure and function to unlock undruggable targets.

We are seeking a Senior/Principal Scientist level medicinal chemist to join our chemistry team. This position will be responsible for the medicinal chemistry strategy and delivery on one or more projects. A candidate with experience collaborating with a machine learning team to deliver against project goals is a plus.

Collaborate with cross-functional teams for project needs in a high-paced data-driven environment. Manage chemistry CROs for timely delivery of synthetic efforts. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning for generative design.

Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide from platform validation to patient impact. Contribute to patent applications and scientific publications. Join collaborative, relentless problem solvers that share our passion for impact.

Requirements

PhD in synthetic organic or medicinal chemistry with at least 5 years’ drug discovery experience in pharmaceutical industry or BS/BA in chemistry with at least 10 years’ experience in pharmaceutical industry
Strong modern synthetic background preferred with knowledge of state-of-the-art organic chemistry methodologies
Experience managing external chemistry CROs
Experience collaborating with machine learning teams preferred
Experience with both traditional small molecules and beyond-rule-of-5 therapeutic modalities is a plus
Strong communication and interpersonal skills

Responsibilities

Design and deliver medicinal chemistry strategy on project(s)
Optimize small molecules through analysis of biochemical, biological, and ADME assay data
Manage chemistry CROs for timely delivery of synthetic efforts
Collaborate with cross-functional teams for project needs in high-paced data-driven environment
Collaborate with machine learning team for delivery against medicinal chemistry strategy
Contribute to patent applications and scientific publications