Principal Scientist - Medicinal Chemistry

6d6 days ago

Genentech

South San Francisco, US · Full-time · $144,000 – $269,100

About this role

We advance science so that we all have more time with the people we love. We have an exciting opportunity for a talented chemist to join our Small-Molecule Drug Discovery Chemistry Department. The role focuses on medicinal chemistry in a multi-disciplinary environment.

The successful candidate will design and synthesize analogs for molecular targets. This involves applying innovative structure- and computation-driven design principles. Property-based design principles guide the work in a team-based culture.

Close collaboration occurs with other chemists and various functions. These include Drug Metabolism and Pharmacokinetics, Structural Biology, and Biochemical and Cellular Pharmacology. Additional partners encompass Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology.

Candidates contribute to drug discovery through expertise in synthetic organic chemistry. The position offers relocation benefits and opportunities for impactful research. Submit a Research Summary with your CV to apply.

Requirements

PhD with 0-6 years of post-PhD experience, or equivalent and relevant experience in chemical research
Expertise in modern synthetic organic chemistry demonstrated by at least one first-authored publication
Ability to conduct multi-step syntheses and retrosynthetic analysis of complex molecules
Extensive experience in medicinal chemistry, methodology/catalysis, total synthesis, chemical biology, or physical organic chemistry
Strong verbal and written communication skills
Ability to work collaboratively in teams
For candidates with significant industry experience, prepared to fully disclose details of accomplishments

Responsibilities

Design analogs for molecular targets using structure-driven principles
Synthesize compounds applying computation-driven design principles
Apply property-based design principles to analog synthesis
Conduct multi-step syntheses of complex molecules
Perform retrosynthetic analysis of complex molecules
Collaborate with Drug Metabolism and Pharmacokinetics teams
Partner with Structural Biology and Cellular Pharmacology groups
Engage with Machine Learning, Pharmaceutical Sciences, and disease area Biology

Benefits

Relocation benefits available
Expected salary range of $144,000 - $269,100 based on experience, qualifications, and location
Discretionary annual bonus based on individual and Company performance
Comprehensive benefits detailed at provided link
Equal opportunity employer with accommodations for applicants with disabilities