Senior Principal Scientist - Process Chemistry

18h18 hours ago

Pfizer

Bothell, US · Full-time · $124,400 – $207,400

About this role

Pfizer's purpose is to deliver breakthroughs that change patients' lives, and at the core of this mission is Research and Development. In this role, you will translate advanced science and technologies into impactful therapies and vaccines, encompassing all facets of development from small-scale synthesis to commercial synthetic routes.

You will lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale-up. Your work involves developing fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability while applying modern synthetic organic chemistry principles.

You will drive alignment to project timelines and portfolio strategy, effectively communicating scientific strategy, risks, and solutions to project teams and leadership. Mentoring junior staff and fostering an inclusive, scientifically rigorous, and collaborative environment are key aspects of this role.

This position offers the opportunity to lead technology transfer and partner interactions for external development campaigns, while maintaining an external technical presence through publications and presentations. You will build strong stakeholder relationships across process chemistry and partner functions.

Requirements

PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing.
Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.
Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations.
Strong communication skills with demonstrated collaborative leadership in cross-functional process development teams.
Experience supporting development from preclinical through commercial stages.
Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
Proficient in computational tools such as DynoChem, gPROMS, Visimix, Aspen, Fluent, and Cosmotherm for reaction modeling and simulation.
Experience developing drug-linkers for ADCs, PROTACS, DACs, or other targeted mixed-modality therapeutics.

Responsibilities

Lead technical teams to design, execute, and interpret complex laboratory experiments for route development, process optimization, and scale-up.
Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
Lead authorship of patents, publications, and regulatory documents.
Apply modern synthetic organic chemistry principles, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development.
Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment.
Lead technology transfer and partner interactions to enable external development campaigns.
Build strong stakeholder relationships across process chemistry, partner functions, and project teams.

Benefits

Annual base salary range from $124,400.00 to $207,400.00.
Eligibility for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of base salary.
Eligibility to participate in share-based long-term incentive program.
Comprehensive and generous benefits and programs to support a healthy lifestyle.