Process Chemistry Principal Scientist

1d1 day ago

Vertex

Boston, US · Full-time · $138,000 – $207,000

About this role

The Process Chemistry Principal Scientist is technically self-reliant with an extensive track record of accomplishments. They identify and solve complex problems repeatedly across critical and diverse projects. This role serves as an emerging technical expert, providing reliable and valuable advice to project teams on a regular basis.

Designs and performs sophisticated, technically challenging experiments efficiently and independently, ensuring compliance with applicable regulations and SOPs. Generates effective hypotheses to pursue project goals and sets new experimental direction. Identifies broad implications of results and their impact on overall study.

Develops novel and creative solutions to overcome project obstacles and makes substantive conceptual contributions to project activities and scientific strategies. Provides authoritative technical recommendations broadly within the company regarding own discipline. Serves as a practical manager of CRO interactions and external collaboration.

Works successfully in cross-functional teams with experience drafting documentation for drug substances under cGMP. Manages technology transfer to CROs and solves chemical issues with suppliers. Demonstrates excellent verbal and written communication skills for presentations and reports.

Requirements

Ability and track record of successfully working in cross-functional teams
Experience in drafting, reviewing and submitting required documentation pertaining to the development and preparation of drug substances under cGMP environment
In-depth conceptual knowledge of SOPs and GMPs and ensure compliance with all applicable regulations and SOPs
Experience in writing and transferring developed technology to outside CROs and working with suppliers to solve chemical issues for compound delivery
Excellent verbal and written communication skills to explain difficult or sensitive technical/scientific information and to prepare presentations and reports
Experience and ability to draft CMC sections of INDs or CTAs

Responsibilities

Designs and performs sophisticated, technically challenging experiments efficiently and independently, ensuring compliance with applicable regulations and SOPs
Generates effective hypotheses to pursue project goals and sets new experimental direction
Identifies broad implications of results and their impact on overall study
Develops novel and creative solutions to overcome project obstacles
Makes substantive conceptual contributions to project activities and scientific strategies
Provides authoritative technical recommendations broadly within the company regarding own discipline and occupies a key project role
Serves as a practical manager of CRO interactions and external collaboration

Benefits

Annual bonus and annual equity awards
Medical, dental and vision benefits
Generous paid time off including a week-long company shutdown in the Summer and the Winter
Educational assistance programs including student loan repayment
Generous commuting subsidy
Matching charitable donations
401(k)