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University of Southern Denmark

Postdoc - Medicinal Chemistry

6d

University of Southern Denmark

DK · Full-time · DKK 430,000 – DKK 500,000

About this role

The Department of Physics, Chemistry and Pharmacy at University of Southern Denmark in Odense invites applications for a 1.5-year postdoctoral position in the Section of Chemistry. This role is embedded in a Novo Nordisk Foundation project on semi-synthesis of pleuromutilin derivatives as new antibiotics. The focus is on design and synthesis of novel antibacterial agents.

The successful candidate will join an interdisciplinary team working to combat multi-resistant infections through innovative chemical strategies. The project develops new antibiotics based on pleuromutilins targeting Gram-negative pathogens. It involves semi-synthetic approaches to generate derivatives with improved activity and decreased resistance potential.

The research group specializes in design and synthesis of antibiotics and modified nucleic acids. It has access to state-of-the-art facilities within synthesis, purification and spectroscopy. The lab engages in on-site collaborations with theoretical chemistry, pharmacy and clinical microbiology.

Contribute to solving society's challenges within health and sustainability at the department. Build bridges between disciplines in physics, chemistry and pharmacy. Explore intersections across natural sciences in an internationally recognized environment.

Requirements

  • Ph.D. in medicinal chemistry
  • Strong expertise in synthetic organic chemistry including multi-step synthesis
  • Documented experience in lead optimization
  • Structure-activity relationship (SAR) development
  • Physicochemical property tuning and scaffold modification
  • Strong track record in medicinal chemistry
  • Knowledge of drug-property tuning (ADMET)
  • Experience with antibacterial drug design

Responsibilities

  • Design novel antibacterial agents targeting multi-resistant Gram-negative pathogens
  • Synthesize pleuromutilin derivatives using semi-synthetic approaches
  • Introduce modifications to natural product Pleuromutilin for improved activity
  • Develop structure-activity relationships (SAR)
  • Tune physicochemical properties and scaffold modifications
  • Conduct multi-step synthesis in medicinal chemistry
  • Optimize leads to decrease resistance potential

Benefits

  • Access to state-of-the-art facilities in synthesis purification and spectroscopy
  • On-site collaborations with theoretical chemistry pharmacy and clinical microbiology
  • Part of Novo Nordisk Foundation project on new antibiotics
  • Interdisciplinary research environment at Faculty of Science