About this role
Bicycle Therapeutics develops Bicycle® molecules, fully synthetic short peptides constrained by small molecule scaffolds for high-affinity target binding. Your mission applies deep expertise in synthetic and medicinal chemistry to design novel Bicycle® molecules and conjugates. Lead chemistry workstreams to advance the oncology pipeline toward clinical candidates.
Take a leading role in project teams designing bioactive Bicycle® peptides aligned with Target Product Profiles. Manage external CROs by developing workplans, tracking progress, and ensuring high-quality compound delivery. Critically evaluate analytical data including NMR, LCMS, and HPLC to troubleshoot challenges.
Interpret SAR data on activity, selectivity, and DMPK using structure-based drug design to optimize leads. Collaborate with cross-functional scientists across Platform, Biology, DMPK, Pharmacology, and CMC. Prepare reports, draft patent applications, and present findings in team meetings.
Contribute to new chemical innovations expanding the Bicycle platform capabilities. Embrace company culture as Adventurous, Dedicated to Mission, and One Team. Help deliver therapies for underserved diseases including oncology through company-sponsored clinical trials.
Requirements
- Deep expertise in synthetic and medicinal chemistry
- Proficiency in structure-based drug design
- Experience interpreting SAR data including activity, selectivity, and DMPK properties
- Proven ability managing external CROs for chemistry synthesis and delivery
- Skilled in evaluating analytical data from NMR, LCMS, and HPLC
- Knowledge of peptide chemistry and constrained peptide optimization
- Cross-functional collaboration in drug discovery teams
Responsibilities
- Lead chemistry activities within project teams, contributing to design and synthesis of novel bioactive Bicycle® peptides
- Apply structure-based drug design expertise to interpret SAR data (activity, selectivity, DMPK) and guide lead compound optimisation
- Contribute to introduction and development of new chemical innovations expanding platform capabilities
- Manage chemistry activities at external CROs, developing detailed workplans and ensuring timely delivery of data and compounds
- Critically evaluate analytical data (NMR, LCMS, HPLC) from CROs and troubleshoot synthetic challenges
- Collaborate with cross-functional teams across Platform, Biology, DMPK, Pharmacology, and CMC
- Prepare detailed reports, contribute to patent applications, and present research findings in meetings
Benefits
- Embrace Adventurous culture delivering extraordinary patient results
- Dedicated to mission changing the world through determination
- One Team environment succeeding together
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