Senior Scientist - Medicinal Chemistry

6d6 days ago

Amgen

Thousand Oaks, US · Full-time · $123,777 – $167,463

About this role

At Amgen, join the shared mission to serve patients living with serious illnesses. As Senior Scientist - Medicinal Chemistry, be part of an innovative Medicinal Chemistry group designing, synthesizing, and purifying novel compounds for potential clinical drug development. Work within Amgen’s Induced Proximity Platform focused on PROTAC modality for intractable targets.

This onsite laboratory position involves devising and implementing state-of-the-art scientific research through conducting experiments and planning detailed procedures with timelines, milestones, and resources. Review, analyze, and interpret scientific data, providing regular updates and documentation on project results. Collaborate with other scientists while keeping current with literature and technology developments.

Thrive in Amgen’s award-winning collaborative, innovative, and science-based culture. Since 1980, pioneer biotech against the world’s toughest diseases across Oncology, Inflammation, General Medicine, and Rare Disease. Reach millions of patients each year through research, manufacturing, and delivery of innovative medicines.

Transform the lives of patients while transforming your career. Participate in national and international meetings, generate publications or patents, and mentor research associates. Make a lasting impact helping people live longer, fuller, happier lives.

Requirements

Doctorate degree OR Master’s degree and 3 years of laboratory experience OR Bachelor’s degree and 5 years of laboratory experience
Doctorate degree in chemistry specializing in organic synthesis
2+ years of experience in synthetic organic or medicinal chemistry
Consistent track record of academic accomplishments (e.g., peer-reviewed publications and/or patents)
Demonstration of good lab practices, with particular attention to safety
Clear understanding of structural determination using NMR and MS techniques as well as knowledge of related purification methods
Initial understanding of biological and pharmaceutical principles and working knowledge of structure-based or other computer-aided drug design tools
Knowledge of the application of parallel synthesis techniques to synthetic or medicinal chemistry

Responsibilities

Design, synthesize, and purify novel compounds for potential clinical drug development
Work within Amgen’s Induced Proximity Platform (IPP) focused on PROTAC modality
Devise and implement state-of-the-art scientific research through conducting laboratory experiments
Plan detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results, and necessary resources
Review, analyze, and interpret scientific data and results
Provide regular updates, documentation, and communication on project results
Collaborate with other scientists and keep current with field of expertise including literature and technology development
Advise supervisors and colleagues in areas of expertise, participate in meetings, support publications or patents, and mentor research associates