Scientist - Protein Engineering - Organic Chemist (ADC)

22h22 hours ago

Amgen

Thousand Oaks, US · Full-time · $111,695 – $151,117

About this role

At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech against tough diseases. We focus on Oncology, Inflammation, General Medicine, and Rare Disease to reach millions of patients yearly.

In this vital role, work at the interface of synthetic chemistry, biochemistry, and chemical biology. Apply synthetic skills to develop ADC therapeutics and cutting-edge novel modalities. Design and generate antibody-drug conjugates to support therapeutic discovery.

Our award-winning culture is collaborative, innovative, and science-based. Thrive with a passion for challenges and opportunities. Work comfortably within a team of scientists and engineers with diverse technical and cultural backgrounds.

Make a lasting impact on patients’ lives through research, manufacturing, and delivery of innovative medicines. Transform lives of patients while transforming your career. Benefit from Total Rewards Plan supporting professional growth and well-being.

Requirements

Doctorate degree OR Master’s degree and 2 years of organic chemistry and laboratory experience OR Bachelor’s degree and 4 years of organic chemistry and laboratory experience
Strong proficiency in organic synthesis and chemical methodology development
Knowledge of or experience with protein conjugation and protein chemistry techniques
Robust understanding of structural determination using NMR and MS
Proficiency in chromatographic techniques (HPLC, RP-HPLC, ion exchange, and size-exclusion chromatography)
Demonstration of good lab practices with particular attention to safety

Responsibilities

Design, synthesize, purify, and characterize linker-payloads for antibody-drug conjugates (ADCs)
Design and generate ADCs, including conjugation, purification, and characterization to support therapeutic discovery
Analyze and interpret data, and communicate results through clear documentation, reports, and project updates
Apply synthetic chemistry skills to protein engineering for ADC development
Develop novel linker-payload combinations and conjugation strategies
Perform biophysical characterization of ADCs using analytical techniques
Support pipeline advancement in oncology and rare disease therapeutics

Benefits

Total Rewards Plan comprising health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Collaborative culture supporting professional and personal growth and well-being