Senior Scientist / Principal Scientist - Process Chemistry

Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, seeks an experienced small molecule process chemist. The role drives development, scale-up, and commercial readiness of the small molecule clinical-stage portfolio. It centers on close collaboration with the medicinal chemistry team within discovery.

The scientist leads from the bench, designing and executing synthetic strategies for drug discovery programs. Focus areas include route invention, reaction development, and scalable synthesis of key intermediates and drug candidates. Responsibilities emphasize modern synthetic methodologies and efficient route design for early scalability.

Collaborate with cross-functional teams including Medicinal Chemistry, DMPK, Toxicology, Drug Product, and Analytical Sciences. Develop practical routes supporting SAR exploration and material delivery for biological and toxicology studies. Manage external partners to support program objectives.

Enable drug discovery through innovative synthetic strategy and solve complex synthetic challenges. Translate discovery chemistry into scalable processes for clinical supply. Advance cross-disciplinary progress toward therapeutic innovation and commercial readiness.