Principal Scientist - Process Chemistry

1d1 day ago

Pfizer

Bothell, US · Full-time · $106,000 – $171,500

About this role

The Chemical Process and Analytical Development (CPAD) group in Bothell, WA develops innovative and phase-appropriate synthetic routes and scalable chemical processes for novel small molecule targeted therapeutics. Process chemists, analytical scientists, and chemical engineers collaborate to design robust, safe, and scalable chemistry. This accelerates delivery of life-changing therapeutics to patients.

As Principal Scientist, Process Chemistry, you will serve as a key technical leader driving route scouting, synthetic design, process development, and process characterization for an expanding portfolio. Apply a strong foundation in modern synthetic organic chemistry and process development to build scalable, innovative chemistry. Use state-of-the-art technologies like HTE, data-rich experimentation, continuous processing, catalysis, and predictive tools.

This role offers hands-on laboratory innovation while guiding strategy for early and late-stage programs. Mentor junior scientists, influence cross-functional project direction, and represent process chemistry internally and externally. Oversee execution of GMP production batches through technology transfer and campaign oversight.

Collaborate across CPAD, partner functions, and project teams to drive alignment to project timelines and portfolio strategy. Foster an inclusive, scientifically rigorous, and collaborative environment. Establish an external technical presence through publications and presentations.

Requirements

PhD in Organic Chemistry with 4+ years of industry experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing; or a Master’s degree with 10+ years of relevant experience.
Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.
Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations.
Strong communication skills with ability to collaborate across scientific and engineering disciplines.
Experience supporting development from preclinical through commercial stages.
Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.
This is an on-site role (5 days/week).
Submission of a research summary is required.

Responsibilities

Design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale-up.
Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
Maintain rigorous laboratory records, author patents, and contribute to regulatory documents.
Apply modern synthetic organic chemistry principles, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development.
Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment.
Lead technology transfer and partner interactions to enable external development campaigns.
Build strong stakeholder relationships across CPAD, partner functions, and project teams.