Senior Scientist - Medicinal Chemistry

1d1 day ago

Merck Group

Billerica, US · Full-time · $111,100 – $166,600

About this role

EMD Serono in Billerica, MA seeks a Senior Scientist – Medicinal Chemistry for the Oligonucleotide Therapeutics Group (DDTech). Join the Healthcare team united as one for patients, developing medicines in Oncology, Neurology, and Fertility. Help create, improve, and prolong lives with innovative technologies across 6 continents.

Implement modern peptide chemistry and conjugation methodologies to accelerate miniprotein drug development optimization. Design and execute receptor expression profiling, ligand-receptor binding, internalization, and trafficking assays. Drive innovation to improve circulating half-life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads.

Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success. Establish high-resolution analytical methods and pipelines using HPLC (SEC, IEX, IPRP) and LC-MS for in-process testing and finished product QC. Work in a diverse, inclusive, and flexible culture passionate about science and technology.

Our global colleagues innovate to enrich lives in Healthcare, Life Science, and Electronics. Become part of relentless curiosity helping patients at every stage of life. Explore great opportunities for personal development and career advancement across the globe.

Requirements

PhD in Medicinal Chemistry, Synthetic Organic Chemistry, Chemical Biology, or other Science field with 5+ years of industry experience
Strong technical background in nucleoside chemistry, peptides, and small molecules
Strong track record of laboratory-based innovation and problem-solving in drug discovery including optimization of affinity, selectivity, drug properties, and PK profile
Proven expertise in hands-on peptide synthesis
Expertise in analytical characterization (e.g. SEC-HPLC, NMR, IEX, IPRP, LC-MS)
Excellent communication skills for both technical and non-technical audiences
Exceptional communication skills with the ability to translate complex data internally as well as with CROs

Responsibilities

Implement modern peptide chemistry and conjugation methodologies to accelerate optimization of miniprotein drug development
Design and execute receptor expression profiling, ligand-receptor binding, internalization, and trafficking assays
Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success
Establish high-resolution analytical methods and pipelines for in-process testing and finished product QC using HPLC (SEC, IEX, IPRP) and LC-MS
Drive innovation to improve circulating half-life, tissue penetration, cellular uptake, and intracellular bioavailability of payloads

Benefits

Pay Range: $111,100 - $166,600
Diverse, inclusive and flexible working culture
Great opportunities for personal development and career advancement across the globe