Director, Medicinal Chemistry / Chemical Biology

16h16 hours ago

Bayer

Cambridge, US · Full-time · $177,771 – $266,657

About this role

At Bayer, visionaries solve the world’s toughest challenges, striving for a world where 'Health for all, Hunger for none' is reality. We're seeking an experienced Medicinal Chemist / Drug Hunter with strong Chemical Biology background to join our dynamic team. Leverage expertise in chemistry and biology to drive innovative therapeutic solutions in cardiovascular research and oncology.

Lead small molecule drug discovery projects from hit identification through lead optimization, incorporating biological relevance into design. Design and procure new chemical entities focusing on potency, selectivity, pharmacokinetics, and alignment with biological targets. Coordinate chemistry activities with CRO/external partners for high productivity.

Collaborate closely with cross-functional teams including computational chemists, biologists, pharmacologists, and formulation scientists. Mentor junior team members in drug discovery techniques and strategies. Co-design biochemical/biophysical experiments and cellular studies to evaluate novel compounds' efficacy and mechanism.

Utilize chemical modalities like small molecules, biologics, and peptides to enhance efforts. Analyze experimental data integrating chemical and biological insights to inform decisions. Build a varied, meaningful career in a community of brilliant, diverse minds making real difference.

Requirements

PhD in Organic Chemistry, Chemical Biology, or a related field
Proven expertise in small molecule design and development, complemented by strong understanding of biological mechanisms and cellular pathways
Expert knowledge and fluency in modern drug discovery methods
Familiarity with other modalities such as biologics, peptides, or RNA-based therapeutics and chemical biology/chemoproteomic workflows
Excellent communication skills, with ability to work collaboratively in a team-oriented, global environment
Strong analytical skills and a results-driven mindset

Responsibilities

Lead and manage small molecule drug discovery projects from hit identification through lead optimization, incorporating biological relevance
Design and procure new chemical entities with focus on potency, selectivity, pharmacokinetics, and alignment with biological targets
Coordinate chemistry activities with CRO/external partners to ensure high productivity and efficiency
Collaborate closely with cross-functional teams including computational chemists, biologists, pharmacologists, and formulation scientists
Mentor and guide junior team members in drug discovery techniques and project strategies
Co-design biochemical/biophysical experiments and cellular studies to evaluate efficacy and mechanism of action of novel compounds
Utilize a variety of chemical modalities including small molecules, biologics, and peptides
Analyze and interpret experimental data to inform project direction, integrating chemical and biological insights