Synthetic Organic Chemist

4w1 month ago

Monte Rosa Therapeutics

Basel, CH · Contract · CHF 90,000 – CHF 120,000

About this role

Monte Rosa Therapeutics seeks a highly motivated synthetic chemist to advance our MGD platform. The role is for a scientist with deep expertise in synthetic organic chemistry and a track record in developing novel methodologies for differentiated chemical space.

You will design and develop innovative small-molecule libraries targeting previously undruggable proteins using MGD approaches. You act as a key driver in evolving the chemistry platform through novel synthetic methodologies and reaction design, overseeing synthesis strategies through a global CRO network.

You collaborate closely with multidisciplinary teams including chemistry, biology, and computational sciences to ensure timely project delivery. Integrating biological data such as ADME and pharmacology, you inform compound design and optimization within a highly interdisciplinary environment.

This position calls for scientific creativity and technical excellence to bridge cutting-edge synthetic chemistry with modern medicinal chemistry principles. You will strengthen technical capabilities and document findings through reports, patents, and publications, driving innovation and efficiency.

Requirements

PhD in Synthetic Organic Chemistry; postdoctoral experience in academia or industry preferred
Strong expertise in complex molecule synthesis and/or reaction and methodology development
Demonstrated track record of scientific impact through publications and/or patents
Solid understanding of medicinal chemistry principles and their application in drug discovery
Experience in parallel synthesis would be advantageous
Sound understanding of preclinical drug discovery, including ADME and developability considerations
Familiarity with chemical databases, visualization tools, and molecular modelling (e.g. Maestro)
Awareness of emerging discovery modalities (e.g. DEL, direct-to-biology approaches)

Responsibilities

Design and develop innovative small-molecule libraries targeting previously undruggable proteins using MGD approaches
Act as a key driver in the evolution of the chemistry platform through the development of novel synthetic methodologies and reaction design
Plan and oversee synthesis strategies executed through a global CRO network
Integrate biological data (ADME, pharmacology) to inform compound design and optimization
Collaborate closely with multidisciplinary teams (chemistry, biology, computational sciences) to ensure timely delivery of project milestones
Strengthen technical capabilities to enhance innovation and efficiency
Document and communicate scientific findings through internal reports, patents, and peer-reviewed publications