Senior Scientist - Medicinal Chemistry Discovery

6d6 days ago

Monte Rosa Therapeutics

Basel, CH · Full-time · CHF 150,000 – CHF 200,000

About this role

Monte Rosa Therapeutics seeks an enthusiastic, creative and highly talented medicinal chemist eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable. This position plays a key role in contributing to the development of our growing portfolio. It will have a crucial impact at the forefront of drug discovery.

The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge. Analyze High Throughput Screening (HTS) output to identify promising starting points from our growing MGD library. Serve as a chemistry project lead against multiple early-stage projects across different disease areas.

Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists. Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team. Efficiently execute compound syntheses through our CRO network by devising efficient synthetic routes.

Collaborate with external research partners and communicate scientific findings to senior leadership and governance. Familiarity with key concepts and optimization strategies in medicinal chemistry including ADME properties. Summarize and publish findings in manuscripts and patents when appropriate.

Requirements

PhD in synthetic organic/medicinal chemistry with 5+ years of experience in pharmaceutical/biotech industry, or MS with 12+ years of experience
Deep experience of High Throughput Screening analysis and follow-up
Familiarity with early stages of pre-clinical research in drug discovery
Experience of collaborating with CROs is essential
High level of proficiency with databases, data analysis and visualization tools (e.g. Spotfire, D360, CDD, Maestro, Pymol)
Proficiency in complex molecule synthesis and/or synthetic method development experience
Apply state-of-the-art medicinal chemistry design principles to MGD discovery
Excellent teamwork skills and the ability to work effectively in global, cross-disciplinary drug discovery teams

Responsibilities

Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library
Serve as a chemistry project lead against multiple early-stage projects across different disease areas
Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists
Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation
Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team
Provide chemistry progressability assessments for early targets
Efficiently execute compound syntheses through our CRO network by devising efficient synthetic routes
Communicate scientific findings and project updates to senior leadership and governance