Research Chemist

1d1 day ago

Convergent Research

Watertown, US · Full-time · $120,000 – $160,000

About this role

Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology to explore new biological frontiers. Protein dysfunctions cause diseases like Alzheimer’s, yet proteins remain understudied due to technological hurdles. PTI develops mass tags for multiplexed protein analysis by mass spectrometry, targeting 100-fold throughput increase.

The Research Chemist will lead design of new labeling methods for mass tag development as an individual contributor with experience in small molecule/peptide labeling chemistries. This involves working with single cell ’omics pipelines, optimizing for LC-MS systems and downstream analysis. A cover letter is required for serious consideration.

The role is in a highly interdisciplinary team environment with scientists, engineers, and mathematicians. PTI supports open research and educational opportunities for rapid career development. Members lead projects with industry-level resources.

Discoveries will disseminate through publications, presentations, and public data portals to the biomedical community. Proof of principle technology is at parallelsq.org. Commit to diversity, inclusion, and cultural awareness in all interactions.

Requirements

5+ years of experience in medicinal chemistry in a professional setting OR PhD in Chemistry or Chemical Biology or related field
Experience in optimizing organic chemistry reaction conditions
Strong quantitative and analytical skills, with a proclivity for reasoning from first principles
Highly motivated and organized researcher with strong analytical skills
Experience with mass spectrometry (LC-MS) analysis of small molecules, peptides or proteins
Experience in synthesizing small molecules for protein modification
Strong foundation in diverse synthetic transformations and reaction strategies

Responsibilities

Discover and optimize new labeling chemistries for covalent modification of proteins and peptides
Develop and optimize sample clean-up approaches
Define new directions for technology development that can unlock new testable hypotheses
Mentor scientists and research associates
Prepare internal reports and manuscripts and present results at internal or external scientific meetings
Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions and communications
Other duties as assigned

Benefits

Opportunity to change the world and work with smartest experts from different fields
Excellent medical, dental, and vision insurance with many $0 premium options and over 20 plan choices
Company-paid group life, AD&D, long- and short-term disability insurance
15 days PTO + 10 sick days