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General Proximity

Scientist II/Senior Scientist - Medicinal Chemistry

2d

General Proximity

San Francisco, US · Full-time · $160,000 – $220,000

About this role

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges. We are seeking a first-rate medicinal chemist to help pioneer this uncharted frontier of drug discovery.

In this role you will design and advance medicinal chemistry strategies for next-generation IPMs including PROTACs. You will lead compound design and SAR campaigns from hit finding through lead optimization while managing external chemistry CROs.

You will partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical biophysical and cellular assays. This fast-moving startup environment places you at the intersection of chemistry biology and platform innovation with direct impact on program direction.

This is a rare opportunity to help build a next-generation drug discovery company from the ground up. You will contribute directly to the creation of a novel class of therapeutics while supporting intellectual property strategy and mechanistic studies.

Requirements

  • Deep medicinal chemistry expertise
  • Creativity urgency and a rigorous builder’s mindset
  • Experience leading compound design and SAR campaigns
  • Ability to manage external chemistry CROs and DMPK studies
  • Strong cross-functional collaboration with biology and platform teams

Responsibilities

  • Design and advance medicinal chemistry strategies for next-generation induced proximity medicines including PROTACs and related modalities
  • Lead compound design and SAR campaigns from hit finding through hit-to-lead and lead optimization
  • Manage external chemistry CROs including compound design prioritization synthetic execution timelines and data review
  • Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression
  • Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical biophysical and cellular assays
  • Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction
  • Support intellectual property strategy