About this role
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery and development of targeted protein degradation medicines for cancer and inflammatory diseases. We seek a talented Senior Scientist with expertise in synthetic organic chemistry to join our medicinal chemistry group in Houston. The position centers on creating degrader-based small molecules to address unmet medical needs.
The scientist will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. Work involves rational structure-based drug discovery enabled by computational and structural biology groups. Contributions include patent, report and scientific publication writing along with process improvements.
As part of a dynamic multi-disciplinary team, collaboration occurs with scientists within Nurix and external collaborators. The role requires engaging in cross-functional leadership either as project team leader or co-lead. Strong emphasis is placed on integrating medicinal chemistry principles with biology and pharmacology knowledge.
Opportunities exist to initiate and lead process improvements within the chemistry department. The position offers a chance to direct drug discovery programs toward phase transitions using advanced computational tools and models. This environment supports inventive contributions to new chemical target structures.
Requirements
- Ph.D. in synthetic organic chemistry with 8 – 10+ years pharmaceutical medicinal chemistry industrial experience
- Track record of delivering advanced leads/development candidates
- Excellent knowledge of medicinal chemistry principles with solid understanding of biology, pharmacology, ADME concepts and series SAR
- Strong working knowledge of protein-ligand interactions, conformational and structural analysis; experienced partnering with computational chemists
- Expert in organic synthesis with strong synthetic problem-solving skills and knowledge of current literature
- Proven leadership capability in a cross-functional team setting as project team leader or co-lead
- Ability to manage priorities and advance multiple projects simultaneously
Responsibilities
- Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy
- Engage in rational structure-based drug discovery enabled by computational and structural biology groups
- Collaborate with a broad group of scientists within Nurix and with external collaborators
- Contribute to patent, report and scientific publication writing
- Initiate and lead process improvements within the chemistry department or cross-functionally
- Make inventive contributions towards new chemical target structures or templates for programs
- Evaluate early screening or literature hits
- Gather, document and analyze information from competitive sources such as patents and meetings to guide program strategy
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