About this role
AQEMIA is a drug invention company dedicated to creating entirely new medicines to address major unmet medical needs. At the core is QEMI, our proprietary molecule-invention platform combining physics-based modeling, statistical mechanics, and generative AI to design novel drug candidates from first principles. As a Medicinal Chemist, you will work at the interface of chemistry and biology, designing and optimizing compounds from hit generation through to preclinical candidates.
Of primary importance: closely collaborate with our technological platform, including atomistic calculations and generative AI, to challenge and improve the platform while designing innovative molecules. Optimize lead compounds and transform them into drug candidates, pragmatically applying our technology. Autonomously execute and interpret complex activities to identify pharmaceutical candidates.
AQEMIA brings together a diverse, multidisciplinary team of 65+ professionals based in Paris and London, including chemists, physicists, machine learning experts, and software engineers. This close collaboration across disciplines enables tackling complex scientific challenges from first principles. Team members contribute expertise, learn from one another, and shape the future of drug invention.
Our most advanced preclinical programs are currently in vivo optimization, targeting diseases still waiting for effective treatments. Research focuses on inventing never-before-seen molecules without relying on experimental data. Join to leverage scientific expertise and build the future of therapeutics.
Requirements
- PhD in synthetic or organic chemistry, academic post-doc is a plus
- 10 years of experience in industrial drug discovery with similar role
- Strong track record in organic synthesis and compound design for drug discovery
- Strong interest in AI-driven and computer-assisted drug design
- Proven ability to work with interdisciplinary teams and effectively communicate complex data
- Familiarity with molecular modeling, SAR analysis, and ADME optimization
- Excellent problem-solving skills and a track record of scientific innovation
- Ability to thrive in a fast-paced, collaborative environment
Responsibilities
- Closely collaborate with technological platform including atomistic calculations and generative AI to challenge platform and design innovative molecules
- Optimize lead compounds and transform them into drug candidates pragmatically applying technology
- Autonomously execute and interpret complex activities to identify pharmaceutical candidates
- Prepare and follow tasks given to CROs to support drug discovery projects including synthesis of novel small molecules and generation of biological data
- Follow and drive one or several programs simultaneously in medicinal chemistry
- Contribute to patent filings
- Maintain clear accurate written records of decisions and progress
- Collaborate with project managers to establish clear projections in terms of timelines and costs
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