Principal Scientist / Senior Principal Scientist - Process Chemistry

6w1 month ago

Zoetis

Kalamazoo, US · Full-time · $150,000 – $210,000

About this role

The Principal Scientist / Senior Principal Scientist is an experienced scientific leader within process chemistry, leveraging advanced knowledge across multiple disciplines to innovate, troubleshoot, and optimize complex chemical syntheses and scale-up processes.

This role requires a highly motivated and independent leader with a proven track record in pharmaceutical or veterinary medicine research and development, capable of driving projects from lead candidate identification through commercial process technical transfer.

The successful candidate will lead multi-disciplinary teams, applying deep technical expertise to independently design and execute complex experiments and projects, often in ambiguous situations with significant uncertainty.

As a key scientific resource, the incumbent influences strategic direction, drives novel experimental approaches across multiple projects, and ensures alignment of work with departmental and organizational goals while mentoring colleagues.

Requirements

Ph.D. in Synthetic Organic Chemistry
Minimum of 8 years of industry experience in pharmaceutical or veterinary medicine process chemistry research and development
At least 2 years of leadership experience managing teams or projects
Broad expertise in modern synthetic organic chemistry with a track record of strategic and innovative solutions to synthetic problems
Proficiency in chemical literature

Responsibilities

Lead process chemistry efforts, including design, development, and scale-up of chemical syntheses for novel veterinary therapeutics.
Independently design, scale-up, and optimize synthetic processes from mg to multi-kilogram scale.
Apply the principles of green chemistry in API process design to select safer solvents and reagents, minimize waste, and improve overall efficiency.
Develop and execute impurity control strategies to ensure product quality, safety and regulatory compliance.
Lead technology transfer activities to commercial manufacturing facilities ensuring processes are safe, robust, economical, and environmentally responsible.
Prepare and review technical and regulatory documentation, including CMC dossiers and development reports.
Mentor and supervise colleagues, providing guidance, coaching, and career development support.
Contribute to intellectual property strategy, including the protection and filing of small molecule IP.