Principal Scientist, Process Chemistry

5w1 month ago

Pfizer

Bothell, US · Full-time · $106,000 – $176,600

About this role

This Principal Scientist role in Pfizer's Chemical Process and Analytical Development (CPAD) group focuses on developing chemical processes for novel drug-linkers used in antibody-drug conjugates (ADCs). You will provide technical leadership to a team of process chemists, driving the development of safe and scalable chemistry to accelerate delivery of life-saving cancer therapies.

In this role, you will design and execute laboratory experiments involving complex data analysis while employing state-of-the-art technologies like high-throughput experimentation and continuous processing. You will lead technology transfers to internal sites or external CDMOs for GMP manufacturing, managing CRO/CMO resources to advance Pfizer’s oncology portfolio.

The CPAD group in Bothell, WA, collaborates with process chemists, analytical chemists, and chemical engineers to discover phase-appropriate synthetic routes. You will promote a supportive and inclusive work environment while mentoring junior staff members and building strong relationships with cross-functional teams and stakeholders.

As a technical leader, you will establish an external presence by authoring journal articles and presenting at leading scientific meetings. You will be expected to bring strategic solutions to management and represent process chemistry in cross-functional initiatives, driving both early and late-phase pharmaceutical development.

Requirements

PhD in Chemistry or related field.
Expertise in synthetic organic chemistry and process development.
Proven track record of delivering safe and scalable chemical processes.
Experience with high-throughput experimentation and data-rich experimentation.
Familiarity with antibody-drug conjugates (ADCs) and drug-linker technologies.
Demonstrated ability to lead technology transfer and manage CDMO relationships.
Strong publication record and experience presenting at scientific meetings.
Ability to mentor junior staff and work collaboratively in cross-functional teams.

Responsibilities

Design and execute well-planned laboratory experiments that require complex data analysis.
Employ state-of-the-art technologies including high-throughput experimentation, data-rich experimentation, computational tools, and predictive software to accelerate process development.
Drive technical aspects of early and late phase pharmaceutical development.
Lead technology transfer to internal sites or external CDMOs for GMP manufacturing while managing CRO/CMO resources.
Persuasively communicate abstract concepts, ideas, and solutions to project teams, leadership, and cross-functional teams.
Serve as a technical and strategic leader for early and late-phase programs while mentoring junior staff members.
Establish an external presence as a technical leader by authoring journal articles and presenting at leading external scientific meetings.
Lead authoring for patents and regulatory documents.