Principal Scientist - Process Chemistry

5w1 month ago

Pfizer

Bothell, US · Full-time · $106,000 – $176,600

About this role

Pfizer's Process Research and Development team translates advanced science into therapies that matter most, accelerating the delivery of best-in-class medicines to patients worldwide. The Chemical Process and Analytical Development (CPAD) group in Bothell, WA, focuses on developing chemical processes and analytical methods for novel drug-linkers used in antibody-drug conjugates (ADCs).

As a Principal Scientist, you will provide technical leadership to a team of process chemists engaged in route screening, process development, and characterization for a growing drug-linker portfolio. You will drive the development of safe and scalable chemistry by leveraging state-of-the-art technologies such as high-throughput experimentation, data-rich experimentation, catalysis, continuous processing, and predictive technologies.

You will spearhead the advancement of Pfizer's oncology portfolio through personal laboratory effort and oversee external resources via technology transfer and campaign execution at CDMOs. You will serve as a technical and strategic leader for both early- and late-phase programs while mentoring junior staff in a supportive and inclusive work environment.

This role offers the opportunity to establish an external presence as a technical leader in the field by authoring journal articles and presenting at leading scientific meetings. You will propose technical and strategic solutions to management and represent process chemistry in cross-functional teams, building strong relationships with stakeholders to advocate for the department.

Requirements

PhD in Chemistry or a related chemical sciences field.
Recognized as a technical leader internally and externally with a record of authoring publications and presenting externally.
Deep expertise in process chemistry, route screening, and scalable synthetic process development.
Experience with state-of-the-art technologies such as high-throughput experimentation, data-rich experimentation, catalysis, continuous processing, and predictive technologies.
Proven ability to lead technology transfer and manage external resources at CDMOs for GMP manufacturing.
Strong strategic and technical leadership skills for both early- and late-phase programs.
Excellent communication skills to persuasively convey abstract concepts to cross-functional teams and leadership.
Experience mentoring junior staff and fostering an inclusive work environment.

Responsibilities

Design and execute well-planned laboratory experiments that require complex data analysis.
Employ state-of-the-art technologies including high-throughput experimentation, data-rich experimentation, computational tools, and predictive software to accelerate process development.
Drive technical aspects of early and late phase pharmaceutical development for drug-linker candidates.
Lead technology transfer to internal sites or external CDMOs for GMP manufacturing while managing CRO/CMO resources.
Persuasively communicate abstract concepts, ideas, and solutions to project teams, leadership, and cross-functional teams.
Establish and deliver on tight timelines aligned with portfolio goals.
Promote a supportive and inclusive work environment and mentor junior staff.
Lead authoring for patents and regulatory documents.

Benefits

Opportunity to work on cutting-edge antibody-drug conjugate (ADC) therapies for targeted cancer treatment.
Access to state-of-the-art technologies including high-throughput experimentation and continuous processing.
Supportive and inclusive work environment with mentorship of junior staff.
External presence as a technical leader through journal articles and scientific meeting presentations.
Collaboration with cross-functional teams and external CDMOs on impactful pharmaceutical development.