About this role
General Proximity is a seed-stage startup developing next-generation induced proximity medicines (IPMs). Our OmniTAC drug discovery engine co-opts cellular machinery to tackle undruggable targets unapproachable by other modalities. We seek a first-rate medicinal chemist to pioneer this frontier.
You will design medicinal chemistry strategies for IPMs including PROTACs, lead SAR campaigns from hit finding to optimization, and manage external CROs for synthesis and timelines. Direct DMPK studies, interpret in vitro and in vivo data, and drive compound progression.
Work at the intersection of chemistry, biology, and platform innovation, partnering with cross-functional teams. Advance core discovery capabilities in biochemical, biophysical, and cellular assays within a fast-moving startup environment.
This role offers outsized impact building a next-generation drug discovery company from the ground up. Contribute to novel therapeutics, scientific strategy, mechanistic studies, and intellectual property.
Requirements
- Deep medicinal chemistry expertise
- Experience with induced proximity modalities like PROTACs
- Proven ability to lead SAR campaigns in drug discovery
- Skilled in managing external chemistry CROs and timelines
- Proficiency interpreting DMPK and assay data
- Strong cross-functional collaboration with biology teams
- Creativity, urgency, and rigorous builder’s mindset
Responsibilities
- Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including PROTACs and related modalities
- Lead compound design and SAR campaigns from hit finding through hit-to-lead and lead optimization
- Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review
- Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression
- Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays
- Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction
- Support intellectual property strategy
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