About this role
Neurocrine Biosciences is a neuroscience-focused biopharmaceutical company dedicated to discovering life-changing treatments for neurological, neuroendocrine, and neuropsychiatric disorders. The Scientist, Medicinal Chemistry role involves designing, synthesizing, purifying, and characterizing intermediates and bioactive compounds. This position supports the company's purpose to relieve suffering for people with great needs.
Daily responsibilities include utilizing techniques such as column chromatography, high performance liquid chromatography, automated normal phase purification, nuclear magnetic resonance, and parallel or combinatorial synthesis. The role requires preparing technical reports, summaries, protocols, and quantitative analyses. Results are communicated and presented to the project team to facilitate decision making.
This position plays a key role in a multidisciplinary team committed to continuous improvement of the lead optimization process. Team members work together on expeditious identification of development compounds. The environment emphasizes a strong, inclusive, and positive culture based on shared purpose and values.
Opportunities involve rapid optimization of lead molecules using modern technology like automated synthesis and purification. Contribute to designing, planning, and conducting synthesis of intermediates and analog libraries. Join a passionate team relentlessly pursuing medicines for debilitating diseases.
Requirements
- Proficiency in organic synthesis techniques for intermediates and bioactive compounds
- Experience with purification methods including HPLC and automated normal phase chromatography
- Skilled in compound characterization using NMR spectroscopy
- Knowledge of parallel and combinatorial synthesis approaches
- Ability to design analog libraries for lead optimization
- Competence in preparing technical reports and quantitative analyses
- Strong presentation skills for multidisciplinary project teams
Responsibilities
- Design, synthesize, purify, and characterize intermediates and bioactive compounds
- Utilize techniques such as column chromatography, HPLC, automated normal phase purification, NMR, and parallel or combinatorial synthesis
- Prepare technical reports, summaries, protocols, and quantitative analyses
- Communicate and present results to the project team to facilitate decision making
- Play key role in rapid optimization of lead molecules using automated synthesis and purification
- Participate in multidisciplinary team for lead optimization and identification of development compounds
- Design, plan, and conduct synthesis of intermediates and analog libraries
Benefits
- Strong, inclusive, and positive culture based on shared purpose and values
- Passionate environment focused on people and relieving suffering
- Work on FDA-approved treatments and robust clinical pipeline
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